Which Mpox Vaccines Are Recommended

The World Health Organization (WHO) announced today that three vaccines are available to prevent mpox in different countries.

Published on August 22, 2024, the WHO's Disease Outbreak News confirmed the MVA-BN® (JYNNEOS®, IMVAMUNE®), LC16-KMB, and OrthopoxVac are available in certain countries. However, OrthopoxVac has not yet been commercialized.

Based on extensive clinical research, the WHO recommends using MVA-BN or LC16 vaccines when the others are not available.  

While the ACAM2000® live vaccinia virus vaccine is authorized to prevent mpox and smallpox infections, the WHO does not recommend it.

Furthermore, mpox vaccination is recommended by WHO and the U.S. CDC for individuals at high risk of exposure, such as when visiting mpox outbreak areas.